Two PhD positions in Molecular modeling and Structural bioinformatics (Montreal, Canada)

Two PhD positions in molecular modeling of metalloproteins are available at the Department of Chemistry and Biochemistry of Concordia University, Montreal, Canada. Research will be performed under the supervision of Prof. Guillaume Lamoureux, Assistant Professor at the Department and member of the Center for Research in Molecular Modeling (http://cermm.concordia.ca/) and of the PROTEO Network (http://www.proteo.ca/en/index.html).

The first project is directed towards understanding how metals such as zinc or calcium affect the structure and function of proteins. Although metal atoms are essential to a large fraction of the chemical reactions in living organisms, they often go undetected in genome-wide studies of protein structures. The project will help to computationally identify which proteins acquire their function from a metal, and what that function is.

The second project is geared towards developing new approaches to simulate chemical reactions in metalloenzymes and understand how their activity can be enhanced or inhibited. The aim is to develop simulation methods that are amenable to high-throughput studies. Depending on the student's interests, the project can be oriented towards either medical (drug discovery), biotechnological (enzyme design), or fundamental questions (understanding living processes).

Requirements:
- M.Sc. degree (or equivalent) in chemistry, physics, bioinformatics, or a related discipline (completed or near completion). Outstanding B.Sc. graduates (with a 3.5/4.0 or higher GPA) may also apply.
- strong quantitative aptitudes (physical chemistry, mathematics, statistics, etc.)
- interest in biochemistry and in computer programming

To inquire, please send an electronic version of your curriculum vitae and scanned copies of your undergraduate and M.Sc. transcripts to Prof. Lamoureux (guillaume.lamoureux@concordia.ca). Upon favorable consideration, you will be invited to apply to the Graduate Program in Chemistry.

The anticipated starting date is January 2012, but a later (or earlier) date can be arranged. Please note that the deadline for applying to the Graduate Program is September 1, 2011.

For more information, see http://faculty.concordia.ca/glamoure.


Guillaume Lamoureux
Department of Chemistry and Biochemistry
Concordia University, Montreal, Canada
http://faculty.concordia.ca/glamoure